Broken Friendship? Opposite Personalities? - Need Advice?

I'd be honest with her... tell her what your feeling, in a sincere way and tell her you want to work on your guys' friendship. If she doesn't agree or can't curb her habits to make you feel comfortable maybe it is better that your not friends. I know its hard but there is no point in wasting your time on a friend that doesn't care about your friendship. To be a real friend you have to be willing to sacrifice and compromise. Maybe you can learn to get involved in things that she's interested in and she can try to stop smoking and instead of partying so much, hang out with you. Anyways best of luck, I hope things work out. The worst thing is to lose a best friend.